分子生物学第十四章重组和修复Recombinationandrepair.ppt
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1、Chapter 14Recombination and repair14.1 Introduction14.2 Breakage and reunion involves heteroduplex DNA 14.3 Double-strand breaks initiate recombination 14.4 Double-strand breaks initiate snapsis14.5 Bacterial recombination involves single-strand assimilation14.6 Gene conversion accounts for interall
2、elic recombination 14.7 Topological manipulation of DNA14.8 Specialized recombination involves breakage and reunion at specific sites 14.9 Repair systems correct damage to DNA 14.10 Excision repair systems in E. coli 14.11 Controlling the direction of mismatch repair 14.12 Retrieval systems in E. co
3、li 14.13 RecA triggers the SOS system 14.14 Eukaryotic repair systemsBivalent is the structure containing all four chromatids (two representing each homologue) at the start of meiosis.Breakage and reunion describes the mode of genetic recombination, in which two DNA duplex molecules are broken at co
4、rresponding points and then rejoined crosswise (involving formation of a length of heteroduplex DNA around the site of joining).Site-specific recombination occurs between two specific (not necessarily homologous) sequences, as in phage integration/excision or resolution of cointegrate structures dur
5、ing transposition.Synapsis describes the association of the two pairs of sister chromatids representing homologous chromosomes that occurs at the start of meiosis; resulting structure is called a bivalent.Synaptonemal complex describes the morphological structure of synapsed chromosomes.Transpositio
6、n refers to the movement of a transposon to a new site in the genome.14.1 IntroductionFigure 14.1 Recombination occurs during the first meiotic prophase. The stages of prophase are defined by the appearance of the chromosomes, each of which consists of two replicas (sister chromatids), although the
7、duplicated state becomes visible only at the end. The molecular interactions of any individual crossing-over event involve two of the four duplex DNAs.14.1 IntroductionFigure 1.22 The ABO blood group locus codes for a galactosyltransferase whose specificity determines the blood group.14.1 Introducti
8、onBranch migration describes the ability of a DNA strand partially paired with its complement in a duplex to extend its pairing by displacing the resident strand with which it is homologous.Hybrid DNA is another term for heteroduplex DNA.Recombinant joint is the point at which two recombining molecu
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