六篇九章白血病ppt课件.ppt
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1、第六篇 血液系统疾病 第九章白血病(Leukemia)周剑峰周剑峰学时数:学时数:3 3学时学时讲授目的和要求1.掌握急、慢性白血病的临床表现,实验室检查及诊断标准,治疗原则2.熟悉急性白血病FAB分型,联合化疗的原则,完全缓解的概念讲授主要内容概述病因和发病机制临床表现实验室检查诊断标准鉴别诊断治疗Erythrocytes:transport oxygenErythrocytes:transport oxygenNeutrophilBasophilEosinophilMonocytes/MacrophageDefense against infectionDefense against in
2、fectionPlatelets:Mediate blood clottingPlatelets:Mediate blood clottingT-lymphocytes:antigen presenting T-lymphocytes:antigen presenting B-lymphocytesB-lymphocytes Plasma cell:Plasma cell:Source of antibodiesSource of antibodiesPluripotential Pluripotential stem cellsstem cellsMyeloid stem cellsMyel
3、oid stem cellsLymphoid stem cellsLymphoid stem cellsUnipotentialUnipotential progenitor cells progenitor cellsImmature Immature hematopoietichematopoietic cells cellsmature mature hematopoietichematopoietic cells cellsHematopoiesis composes of the options of commitment to different Hematopoiesis com
4、poses of the options of commitment to different lineages and the progressive stages of maturation at which partial or lineages and the progressive stages of maturation at which partial or complete arrest can occur,results in the wide array of malignant complete arrest can occur,results in the wide a
5、rray of malignant disease-Leukemiadisease-LeukemiaStem cell Progenitor cellImmature cellMature cell Accumulation of mutations of DNA within a pluripotential stem cell or very early progenitor cell gives rise to leukemic stem cellsNormal stem cellLeukemic stem cellEtiology&Pathogenesis Environmental
6、factors Acquired diseasesLesions to the DNAClonal expansionA lot of environmental factors has been reported to cause A lot of environmental factors has been reported to cause leukemia.However,only four of them are firmly established leukemia.However,only four of them are firmly established causal ag
7、ents.They are:causal agents.They are:Irradiation exposureIrradiation exposure Chronic benzene exposure Chronic benzene exposure Chemotherapeutic agents Chemotherapeutic agents Leukemia virus infection Leukemia virus infection Environmental factorscause leukemiaInherited syndromes such as ataxia-Inhe
8、rited syndromes such as ataxia-telangiectasiatelangiectasia,down,down syndrome predispose to subsequent development of syndrome predispose to subsequent development of leukemia.Usually,these kinds of syndromes share the leukemia.Usually,these kinds of syndromes share the common features that they al
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